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Shocks to the brain

Electrical impulses help keep Parkinson’s tremors at bay

Saturday, February 25, 2012

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In an activity he couldn’t have performed a few years ago, Pete Peterson walks the family dog, Vixen, on Feb. 8 along Burch Mountain Road. Peterson had a brain operation to insert two rods that electrically stimulate a part of his brain, treating symptoms of his severe Parkinson’s disease.

'It's not a death sentence'

WENATCHEE — Parkinson’s disease is progressive, and there is no cure.

“But I want people to know that it’s treatable,” said Dr. Kelly Condefer, a neurologist at the Wenatchee Valley Medical Center. “It does change your life but it’s not a death sentence.”

There are about 10 medications on the market to help minimize the symptoms, Condefer said. And there is surgery to implant a stimulator in the deep motor centers of the brain.

That surgery has existed for about 20 years, she said. It is not done in Wenatchee. Most people from North Central Washington have it done in Seattle or Spokane.

But neurologists in Wenatchee are trained to monitor when, in the progression of the disease, that surgical treatment may be a good option, Condefer said. Local neurologists can also do pre-surgical tests here, and they are trained to calibrate the intensity of the stimulator after surgery. In the past couple of years, calibration equipment has developed to the point where patients can control stimulator settings on their own.

“It’s like tuning a radio, almost,” Condefer said.

Having a deep-brain stimulator usually allows patients to decrease the amount of medications they are on.

How long will the stimulator work? Condefer said some people have had one in for 20 years. As the disease progresses, however, the stimulator may not be able to help with all symptoms.

Early treatment for Parkinson’s involves medications. The disease is caused by a decrease in the body’s ability to manufacture dopamine, a neurotransmitter critical to movement. Symptoms usually appear when the body loses 80 percent of its ability to produce dopamine, Condefer said. Medication either replenishes dopamine or mimics the action of dopamine.

— Dee Riggs, World staff

Symptoms of Parkinson's disease

•Early symptoms

Mild tremor in one hand

Lowered voice volume with an inability to project very far

Smaller handwriting and difficulty doing repetitive actions with the hands

Arms stop swinging when walking

Scuffing of the feet when walking

•Ongoing problems

Parkinson’s also affects involuntary movements of the body, leading to complications such as:

Overactive bladder

Constipation

•Other problems may include:

Anxiety

Depression

Subtle personality changes such as becoming more quiet or less outgoing

Dementia, in late stages

Source: Dr. Kelly Condefer, Wenatchee neurologist


A possible link to pesticides

Last spring, the National Institutes of Health reported that a study showed a link between use of two pesticides, rotenone and paraquat, and Parkinson’s disease. People in a study, who used either pesticide, developed the disease about 2.5 times more often than non-users..

Rotenone is registered for sale to home gardeners in Washington state under two labels, said Carol Ramsay, pesticide education specialist with Washington State University. The labels are Bonide Garden Dust RT2U, which targets insects and plant pathogens; and Bonide Liquid Rotenone-Pyrethrins Spray Concentrate, which targets insects. Ramey said the amount of rotenone in those products is very small. She also noted that other studies have show that rotonone, which used as directed, is not harmful to human health.

Rotenone is also used to kill invasive fish as part of lake rehabilitation programs operated by the state Department of Fish and Wildlife, according to Madonna Luers, a public information officer for the department. Applicators wear protective gear, and the product breaks down quickly in the water.

Paraquat is not registered for use in Washington state for home and garden products but is registered for pesticide dealers to sell to farmers, Ramsay said. It is primarily used for getting rid of weeds in agricultural crops.

— Dee Riggs, World staff

With the touch of a button, Pete Peterson begins to tremble.

His arms move almost rhythmically back and forth, back and forth, back and forth. He can’t control them.

Parkinson’s disease is in control.

But then Peterson’s wife, Susan, touches a different button on a remote control device and, within seconds, the trembling slows. Within minutes, it’s gone.

A deep-brain stimulator has taken over. The stimulator’s electrical impulses haven’t stopped or slowed the disease but they are masking its symptoms.

The stimulator was implanted in Peterson’s brain in 2009.

“Before the surgery, Pete could not get in and out of bed or a chair by himself, and he had trouble rolling over in bed and he was having trouble speaking,” Susan said.

“After the surgery, he could put on his coat, go out the door and go for a walk. It was a second chance.”

Peterson is one of an estimated 500,000 people in the United States who suffer from Parkinson’s disease, according to the National Institutes of Health. About 50,000 new cases are reported annually.

Neurologists at the medical center are now seeing 370 patients, said Wenatchee neurologist Kelly Condefer.

Nationally, officials with the NIH say, figures are expected to increase as the population ages.

Peterson is one of an estimated 90,000 worldwide who have had a deep-brain stimulator implanted to mask symptoms, Condefer said.

Most people are diagnosed with Parkinson’s when they’re in their 60s or older. For Peterson, the diagnosis came in 2002, when he was 47.

The active outdoorsman, who was working as station engineer for KPQ Radio, was taking karate classes, working toward a black belt, when he experienced pain in one arm. Susan said she also noticed that, when Pete walked, his left arm did not swing naturally, “like it was frozen.”

“In a two-week period, he fell off off a snowmobile and he fell off a horse,” Susan said. “It was like, ‘What’s wrong with this picture.’ “

Tests by a Wenatchee neurologist proved what they’d been dreading.

“I didn’t want to have Parkinson’s,” Pete said. “I knew Michael J. Fox and Muhammad Ali have it, and they didn’t like it.”

“My first thought was about him,” Susan said, “then, later, I was thinking, ‘Whoa, this changes our life plans. We had all these plans for retirement, and it was just like walking into a wall.”

Pete worked another 18 months but then quit. He found that climbing on ladders up to radio antennas was not a safe activity for someone with a movement disorder.

Initially, Pete was denied Social Security disability, making Susan, a public information officer with the U.S. Forest Service, the sole wage-earner. That, they said, was hard on Pete.

Medication worked for several years, but the trembling got worse. In 2008, Pete’s doctor suggested he consider the deep-brain stimulator.

“There is only a small window of opportunity for things to work with the surgery, and then the chances of surgery working start to drop,” Pete said.

“He was to the point where tremors had gone from the left arm into the right arm and had begun to exhibit in all four extremities,” Susan said. “His quality of life was starting to really go down hill.”

Next came six months of testing, which included a psychological profile on both of them.

“You enter into this as a partnership,” Susan said. “If the primary caregiver is not strong enough, mentally, to deal with this, then you are not a candidate for the surgery because you’re both going through it.”

Susan said doctors at Virginia Mason Hospital and Medical Center in Seattle told them there was a small chance that the surgery would harm Pete. “He could become a vegetable,” she said. “That’s the reality.”

They decided to proceed, and, to their great relief, the surgery was successful. Before surgery, Pete was in stage three out of five stages of Parkinson’s. “The surgery took him back to 1.5,” Susan said.

“Which is phenomenal,” Pete said.

Today, Pete walks daily with a friend, who also has Parkinson’s, and Pete and Susan try to do as much together as they can. Recently, they visited the Grand Canyon.

“We are trying to live and do our dreams now, as soon as we can,” Susan said. “Our time frame has changed.”

The couple will, however, be doing things with a lot less money than they had before Pete became ill. Their after-insurance costs for his medications run $600 a month, they say, and all the trips to Seattle set them back thousands of dollars. Susan said the surgery costs $130,000 but, with insurance, they were responsible for $10,000.

Some good news came in 2009, when the government approved Social Security disability for Pete.”That gave him an income, and, after the surgery, there was a dramatic cutback in the medications that he uses,” Susan said.

The Petersons, married since 1982, say they don’t know how long the stimulator will continue to mask symptoms, but they are hoping for several more good years.

“We made a conscious decision to support each other,” Susan said. “We try to prepare for the future but we take it in small steps. We don’t play the ‘What if’ game because that could drive you crazy.”

Dee Riggs: 664-7147

deeriggs@wenatcheeworld.com

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red4ord     1 year, 2 months ago

I suspect this is The Pete Peterson I was priviledged to meet on one occasion: the rescue of our program's 'Wilderness' expedition,after being stranded in 5' of snow for a week. Pete was great, calm and reassuring, he ferried us out of the wilderness area as the pilot of Chelan County Sheriff's helicopter. Only $6000 for twelve passenges who enjoyed the spectacular views that day of Mt. Maude,7 finger Jack, Copper Mt, Bonanza, Glacier Peak, a truely spiritual experience....thanks Pete I'll bet many others have the same gratitude for your professionalism, skill and service.

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11Bravo     1 year, 2 months ago

No red4ord, not the same Pete, I know both Pete's. Pete the pilot was last flying for the DNR when I talked to him a couple years back. He is also a longtime Entiat resident, and retired from the Chelan County Sheriff's office. Pete the pilot is also very excellent pilot who flew Hueys in Vietnam.

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smokeybear     1 year, 2 months ago

Just to let you guys know, both Pete the pilot and Pete "not the pilot" worked together on many rescues as Chelan County Mountain Rescue.

Pete the pilot lives in Entait with his family

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red4ord     1 year, 2 months ago

Thanks for the correction and update. Maybe both Pete's were involved: the whole Sheriff's Posse was waiting in Ice Camp for the helicopter to reconn and find us.

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